Can I Take Nootropics with Wellbutrin?

It is not recommended to take nootropics with Wellbutrin without first consulting with a healthcare professional. Nootropics, also known as cognitive enhancers, are supplements or drugs that are believed to enhance cognitive function, memory, creativity, and motivation. Wellbutrin, on the other hand, is an antidepressant medication that is commonly used to treat depression and seasonal affective disorder.

As more people seek ways to enhance their cognitive abilities, nootropics have become increasingly popular. These supplements are designed to boost brain function, memory, focus, and creativity.

However, many people are unsure whether they can take nootropics with prescription medications like Wellbutrin. If you’re considering taking nootropics while on Wellbutrin, it’s essential to understand the potential interactions between the two. In this article, we’ll explore the effects of taking nootropics with Wellbutrin and what you need to know before starting.

What are Nootropics?

Nootropics, also known as cognitive enhancers or smart drugs, are a class of supplements that improve mental functions like memory, creativity, focus, and motivation. They work by increasing blood flow to the brain, boosting neurotransmitter levels, and protecting brain cells from damage. Nootropics are made up of various compounds, including vitamins, minerals, amino acids, and herbal extracts.

What is Wellbutrin?

Wellbutrin, also known by its generic name Bupropion, is an antidepressant medication that belongs to the class of drugs called aminoketones. It’s commonly used to treat depression, seasonal affective disorder (SAD), and as an aid to quit smoking. Wellbutrin works by blocking the reuptake of dopamine and norepinephrine, two neurotransmitters associated with mood and energy levels.

Can You Take Nootropics with Wellbutrin?

The answer to this question is not straightforward. While some nootropics are generally safe and can be taken with Wellbutrin, others can interact with the drug, leading to adverse effects. Wellbutrin can also interact with other medications, so it’s essential to talk to your doctor before starting any new supplement regimen.

Taking both nootropics and Wellbutrin together could potentially increase the risk of adverse effects, such as agitation, anxiety, and insomnia. Furthermore, some nootropics can interact with Wellbutrin, which may alter its effectiveness or increase the risk of side effects. Therefore, it is crucial to speak with a healthcare professional before taking any new supplement or medication, especially if you are already taking other medications.

Nootropics That Can Be Taken With Wellbutrin

Some nootropics that can be taken with Wellbutrin include:

  • Caffeine: This natural stimulant can increase alertness, focus, and mood. However, it’s essential to watch your caffeine intake while on Wellbutrin, as it can increase the risk of seizures.
  • L-theanine: This amino acid is commonly found in green tea and can help reduce stress and anxiety levels.
  • Creatine: This supplement is commonly used by athletes to improve physical performance, but it can also improve cognitive function.
  • Bacopa monnieri: This herbal extract has been shown to improve memory and reduce anxiety levels.

Nootropics to Avoid While on Wellbutrin

Some nootropics that should be avoided while on Wellbutrin include:

  • Phenibut: This compound is a potent anxiolytic, but it can also cause sedation and dizziness when taken with Wellbutrin.
  • Modafinil: This prescription drug is used to treat narcolepsy and sleep apnea, but it can interact with Wellbutrin, leading to increased blood pressure and heart rate.
  • Racetams: These nootropics, including Piracetam and Aniracetam, can interact with Wellbutrin, leading to adverse effects like headaches and nausea.


In conclusion, taking nootropics with Wellbutrin is possible, but it’s essential to be cautious and informed about the potential interactions between the two. Some nootropics can be taken with Wellbutrin, while others should be avoided. Before starting any new supplement regimen, it’s essential to talk to your doctor to ensure that it’s safe for you. Additionally, always follow the recommended dosage and watch for any adverse effects when taking nootropics or any other supplements. Remember, enhancing cognitive function is not worth risking

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